What is Citicoline?

Definition and History

Citicoline, also known as cytidine diphosphate-choline, is a naturally occurring compound that has garnered considerable attention for its potential benefits on brain health and cognitive function. It plays a critical role in the synthesis of phospholipids, essential components of cell membranes in the brain. Citicoline was first identified and isolated in the 1950s, and since then, it has been the subject of extensive research and investigation.

Citicoline’s chemical structure consists of cytidine, a nucleotide found in RNA, and choline, an essential nutrient involved in various physiological processes. This unique combination makes Citicoline a vital building block for the production of phospholipids, which are crucial for maintaining the structural integrity and fluidity of cell membranes.

Citicoline and Brain Health

Citicoline’s common uses extend beyond brain health. It is utilized in the medical field for the treatment of various neurological conditions, including stroke, traumatic brain injury, and age-related cognitive decline. The therapeutic applications of Citicoline have piqued the interest of researchers, clinicians, and individuals seeking to optimize brain function and overall well-being.

Citicoline’s ability to support brain health and cognitive function has led to its increasing popularity as a dietary supplement. People looking to enhance their mental performance, improve memory and focus, or support their cognitive abilities have turned to Citicoline as a potential ally in achieving these goals.

As research on Citicoline continues to advance, new potential applications and benefits may emerge, providing further insights into the impact of this compound on brain health and cognitive function. Understanding the definition, history, origin, and common uses of Citicoline sets the stage for delving into its specific effects on brain health, stress management, mood, and focus.

Citicoline and Brain Health

Citicoline plays a crucial role in promoting brain health through various mechanisms. As a precursor for phospholipid synthesis, it contributes to the structural integrity and fluidity of cell membranes in the brain. This enhanced membrane integrity is vital for efficient communication between neurons and supports overall neuronal function.

Citicoline also influences the production of neurotransmitters, such as acetylcholine, dopamine, and noradrenaline, which are essential for optimal brain function. By increasing the availability of these neurotransmitters, Citicoline may enhance signaling within the brain and positively impact cognitive processes, such as attention, memory, and learning.

The Role of Citicoline in Cognitive Functions

Cognitive functions encompass a wide range of mental processes, including attention, memory, language, and problem-solving. Citicoline’s impact on cognitive functions stems from its influence on neuronal membranes and neurotransmitter systems.

The enhancement of neuronal membrane fluidity through Citicoline supplementation can improve the efficiency of neuronal communication. This improved communication allows for faster and more precise signaling between neurons, which can positively impact attention, memory formation, and learning processes.

Moreover, Citicoline’s role in neurotransmitter synthesis, particularly acetylcholine, contributes to cognitive functions such as attention and memory. Acetylcholine is involved in regulating attentional processes and facilitating memory formation. By promoting acetylcholine synthesis, Citicoline may enhance these cognitive domains.

The Scientific Evidence Supporting Citicoline’s Effects on Brain Health

Research has shown that Citicoline administration can improve cognitive performance in various populations, including healthy adults, elderly individuals, and those with cognitive impairments. Studies have demonstrated improvements in attention, memory, processing speed, and overall cognitive abilities in individuals receiving Citicoline supplementation.

Additionally, Citicoline has been investigated for its potential neuroprotective properties. Animal and human studies have shown that Citicoline may protect against neuronal damage, reduce inflammation, and enhance neuronal survival and recovery after brain injuries such as stroke and traumatic brain injury.

The scientific evidence supporting Citicoline’s effects on brain health is robust and promising. However, further research is needed to fully elucidate the underlying mechanisms of action and to explore the optimal dosage and treatment duration for different populations and conditions.

Understanding the impact of Citicoline on brain health provides a foundation for exploring its potential in other areas, such as stress management, mood enhancement, and focus. By supporting brain health and cognitive function, Citicoline opens up new possibilities for optimizing mental performance and overall well-being.


  1. Alvarez-Sabín J, Ortega G, Jacas C, et al. Long-term treatment with citicoline may improve poststroke vascular cognitive impairment. Cerebrovasc Dis. 2013;35(2):146-154. doi:10.1159/000346208
  2. Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, Renshaw PF. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl). 2002 Apr;161(3):248-54. doi: 10.1007/s00213-002-1007-2. PMID: 11919625.
  3. Citicoline – Monograph. Alternative Medicine Review. 2008;13(1):50-57.
  4. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature. Altern Med Rev. 2004;9(1):17-31.
  5. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD000269. doi: 10.1002/14651858.CD000269.pub3. PMID: 16235326.
  6. Hurtado O, Moro MA, Cárdenas A, Sánchez V, Fernández-Tomé P, Leza JC, Lorenzo P, Secades JJ, Lozano R, Dávalos A, Castillo J, Lizasoain I. Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis. 2005 Jun-Jul;19(1-2):369-78. doi: 10.1016/j.nbd.2005.01.014. PMID: 15837565.
  7. McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd D. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2019 Jun;23(8):783-791. doi: 10.1177/1087054715588324. Epub 2015 Jun 8. PMID: 26054802.
  8. Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol. 2011 Feb 16;52 Suppl 2:S1-62. PMID: 21385667.
  9. Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008 Nov;21(10):1066-75. doi: 10.1002/nbm.1281. PMID: 18409102.