Atomistic simulations have the potential to elucidate the molecular basis of biological processes such as protein misfolding in Alzheimer’s disease or the conformational changes that drive...
Jan, 01, 2010
It's an exhilarating time for genome-wide association studies
For the past few months it seemed you couldn’t open a journal without reading results of a new genome-wide association study. The results kept pouring in: four studies in April showing seven...
Oct, 01, 2007
How bioinformatics tools are bringing insight to the environmental side of the health equation
When it comes to what kills people, Nurture trumps Nature: Chronic diseases with overwhelmingly environmental (rather than genetic) causes are responsible for the deaths of two-thirds of the world...
Nov, 01, 2016
Building upon the clues provided by GWAS to gain new insights
Some diseases, such as cystic fibrosis, have a beautiful simplicity: A genetic misspelling cripples a protein, which profoundly and predictably alters the body. Find the faulty gene for these so-...
Jan, 12, 2015
Today, if researchers want to study complex relationships among genes, diseases and drugs, they have to hope that human curators have read the scientific literature, extracted the relevant...
Apr, 01, 2016
Different cell types intriguingly varied
Each cell in a person’s body contains the same three billion letter DNA encyclopedia. But the many different cell types throughout the body (brain, bone, heart, skin, etc.) represent different...
Jun, 01, 2015
Ontologies provide biomedical researchers with an inventory of the universal features of reality across organisms, biomedical disciplines, and levels of granularity. In capturing what is universal,...
Jul, 01, 2009
Whole genome sequencing (WGS) and whole exome sequencing (WES), which sequences only the protein-coding regions of the genome, have already begun to transform clinical medicine. They are being used...
Jun, 18, 2014
The recent surge of high-throughput experimental data, such as gene expression microarrays, offers a profound opportunity to gain a more detailed understanding of the genes involved in the...
Jan, 01, 2009
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Apr, 01, 2008
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