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Vertex Classification in Graphs

How can they help us understand proteins?

Graphs, or networks, have been widely adopted in computational biology, with examples including protein-protein interaction networks, gene regulatory networks, and residue interaction networks in...
Jun, 20, 2013
The Top Ten Advances of the Last Decade & The Top Ten Challenges of the Next Decade

A recognition of biocomputing's successes and a prediction of what's to come

The last ten years have seen huge leaps in biomedical computing. We now have new ways to integrate and understand vast quantities of data; the capacity for multi-scale biological modeling; and a...
bioinformatics tools, biomedical computing, CAD, computational modeling, data mining, disease surveillance, dynamic modeling, education, eric jakobsson, function prediction, genetic association, genome annotation, in silico screening, medical informatics, neuromodeling, prosthetics, sequence alignment, structure prediction, systems biology, systems biomedicine, telemedicine, tomography
May, 31, 2005
Diagnosing Cell Circuitry
To biologists, a computer’s motherboard may just look like highways of circuitry connecting various chips. But if they focus harder, they might see a model for disease, according to new...
Dec, 31, 2008
Seizures, In Theory: Computational Neuroscience and Epilepsy

Bridging the scales of computational and experimental research

With the headline “Easing Epilepsy With Battery Power,” the New York Times on March 24, 2014, described an implantable device for controlling epileptic seizures in patients who do not...
Jun, 17, 2014
More Than Fate: Computation Addresses Hot Topics in Stem Cell Research

Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.

To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
stem cell
Mar, 31, 2010
Network Biology—At the Frontier
Living systems are characterized by intricate networks of interactions among tens of thousands of entities within cells and across extracellular milieus. The entities in these networks include such...
Nov, 16, 2017
Top 12 List for Biocomputing: A Decade of Progress and Challenges Ahead

Looking back, and looking forward.

Editor’s Note: In addition to asking 10 experts to weigh in on Eric Jakobsson’s 2005 Top Ten Challenges for the field of biomedical computing (Top Ten Retrospective, in this issue),...
Jun, 17, 2014
Curating Drugs’ Potential with SWEETLEAD

Resolving conflicts among databases

Pharmaceutical research is notoriously expensive. To find safe and effective drugs cost-effectively, some researchers seek new uses for medications that have already leaped the hurdles of the FDA...
Jun, 17, 2014
Profiles in Computer Science Courage Part I: Reflections on the rewards of plunging into biomedicine

Interviews with Leonidas Guibas, Ron Shamir, Michael Black, David Haussler, Daphne Koller, Erin Halperin, Gene Myers, Paul Groth and Bruce Donald

To a computer scientist, the fields of biology and medicine can seem like the vast Pacific Ocean, says Leonidas Guibas, PhD, professor of computer science at Stanford University. “You go to the...
Careers, computer science
Mar, 31, 2011
Taking the leap: from single genes to the molecular choreography of the cell
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Mar, 31, 2008
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