How can they help us understand proteins?
Graphs, or networks, have been widely adopted in computational biology, with examples including protein-protein interaction networks, gene regulatory networks, and residue interaction networks in...
Jun, 20, 2013
Mutual information (MI) is defined in information theory as a measure of the dependencies between two random variables. There are many biomedical applications in which it is beneficial to quantify...
Jun, 30, 2007
T-Rex in the Slow Lane
by Kristen Cobb
Tyrannosaurus rex is often pictured baring its teeth, crouching, and running swiftly after its prey, but these images are largely based on human fancy...
Jan, 01, 2006
Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.
To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
Mar, 31, 2010
Living systems are characterized by intricate networks of interactions among tens of thousands of entities within cells and across extracellular milieus. The entities in these networks include such...
Nov, 16, 2017
Looking back, and looking forward.
Editor’s Note:
In addition to asking 10 experts to weigh in on Eric Jakobsson’s 2005 Top Ten Challenges for the field of biomedical computing (Top Ten Retrospective, in this issue),...
Jun, 18, 2014
Classifying variability of gene expression
Genetically identical cells or organisms grown in identical environments will differ phenotypically, because—even with a common script—gene expression is inherently variable, or noisy....
Mar, 31, 2006
The Human Genome Project has spurred extraordinary developments in our ability to characterize cellular systems in high-throughput fashion. Polymorphism, methylation, gene expression, and proteomics...
Mar, 31, 2008
A newly created molecular computer works in human cells and offers the flexibility of a general-purpose circuit. The advance, described in Nature Biotechnology in May, brings closer the eventual...
Sep, 30, 2007
Network biology is allowing scientists to convert their cellular parts lists into insights about complex diseases
To parents, the symptoms of autism can seem to appear from out of the blue during a child's first few years of life. But in recent years, researchers have shown that genes involved in the...
Nov, 16, 2017
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