How researchers are combining disparate data types and simulating systems that contain many different moving parts
13 years ago Markus Covert, PhD, read a New York Times article that changed his life. The article quoted a prominent microbiologist who suggested that the ultimate test of one’s...
Feb, 16, 2013
Biomodels curates and annotates models for public use
As systems biologists develop models that attempt to simulate life, they need a good way to make them accessible to others as well as a good way to access other people’s models—and to...
Sep, 01, 2005
Simulating how cell membranes form vesicles
Whenever a cell needs to get rid of waste, transport materials, sort proteins, or build new organelles, membranes remodel themselves. Often that means forming small enclosed compartments called...
Jul, 01, 2007
Gene therapy to correct inherited illnesses hinges on successful delivery of DNA into a person’s cells. Most gene therapists work with viruses to ferry their DNA cargo. Yet the body tends to...
Oct, 01, 2009
Disentangling the different types of skeptics and what modelers can learn from each.
What are the telltale signs of a modeling talk at a biology conference? Just look for the sighs, shifting, and eye-rolling in the audience, says Donald C. Bolser, PhD, professor of physiological...
Jun, 05, 2012
Competition inspires model improvements
During the summer of 2009, the International Neuroinformatics Coordinating Facility in Stockholm dangled a nearly $10,000 cash prize in front of neuron modelers and challenged them to do better. And...
Jan, 01, 2010
Confidence boost for modelers
It’s often said that all models are wrong, but some are useful. And one model that certainly falls in the “useful” category is the human lower-limb model that Scott Delp published...
Jun, 01, 2010
Biomedical applications of ABMs are taking off.
In the early 1990s, when James A. Glazier, PhD, first became interested in
using agent-based modeling to simulate biological phenomena, the field was so new that he had to borrow ideas...
Sep, 01, 2013
Injury type matters
When the bones and discs of the spinal column are broken, crushed, or displaced, the spinal cord itself may be devastatingly damaged. Now, a new computer model suggests that the manner in...
Jul, 01, 2008
Medicinal patches applied to the skin are an attractive route for drug delivery since they can release medicine slowly into the bloodstream and avoid being metabolized by the digestive system. Yet...
Oct, 01, 2009
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