Seeking a non-invasive approach to cancer diagnosis and prognosis
In a radiological image, a tumor’s edges might appear fuzzy or crisp; its shape could range from oval to many-lobed; and its density and texture might vary across the tumor. To determine...
Jun, 19, 2013
How increased coverage of the structure space is transforming the field of biology
When the human genome was completely sequenced in 2003, researchers were already pondering how biomedicine could make use of it. One hope was that the sequences would lead to a greater...
Jan, 01, 2010
Cost-effectiveness studies yield answers to the complex question of whether clinical genomics testing has value.
Whole-genome testing has now reached the long-anticipated “$1,000 genome” level; and more targeted genetic panels cost even less. But the costs associated with genomic testing don’t...
Nov, 17, 2017
Can the complexities of biology be boiled down to Amazon.com-style recommendations? The examples here suggest possible pathways to an intelligent healthcare system with big data at its core.
“We have recommendations for you,” announces the website Amazon.com each time a customer signs in.
This mega-retailer analyzes billions of customers’ purchases—nearly $...
Jan, 02, 2012
A new media artwork explores novel ways to represent and intuitively understand nature in the metagenomic era
What’s it like to be immersed in a dataset of millions of DNA sequences? Audiences of ATLAS in silico—a new media artwork that explores novel ways to represent and intuitively understand...
Oct, 01, 2008
And people are starting to notice
In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Apr, 01, 2006
There is growing recognition that epigenetics may be just as important as genetics in human health and disease.
In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
Jun, 01, 2010
Crowdsourced games and competitions fill an important niche
The rules of Phylo are simple: drag colored blocks across rows on the computer screen until similar colors line up. Within minutes of launching the game, any average person can learn how to play and...
Mar, 01, 2014
Different cell types intriguingly varied
Each cell in a person’s body contains the same three billion letter DNA encyclopedia. But the many different cell types throughout the body (brain, bone, heart, skin, etc.) represent different...
Jun, 01, 2015
Why Biomedical Computation Review matters
Ten years ago, when Scott Delp, PhD, and Russ Altman, MD, PhD, decided to write a grant for a National Center for Biomedical Computing (NCBC), their brainstorming sessions with then-postdoc David...
Mar, 01, 2014
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