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Digging Into Pixels: Radiogenomics Extracts Meaning

Seeking a non-invasive approach to cancer diagnosis and prognosis

In a radiological image, a tumor’s edges might appear fuzzy or crisp; its shape could range from oval to many-lobed; and its density and texture might vary across the tumor. To determine...
imaging, radiogenomics
Jun, 19, 2013
Structural Genomics: Exploring the 3D Protein Landscape

How increased coverage of the structure space is transforming the field of biology

When the human genome was completely sequenced in 2003, researchers were already pondering how biomedicine could make use of it.  One hope was that the sequences would lead to a greater...
Dec, 31, 2009
Is Clinical Genomics Testing Worth It?

Cost-effectiveness studies yield answers to the complex question of whether clinical genomics testing has value.

Whole-genome testing has now reached the long-anticipated “$1,000 genome” level; and more targeted genetic panels cost even less. But the costs associated with genomic testing don’t...
Nov, 16, 2017
Big Data Analytics In Biomedical Research

Can the complexities of biology be boiled down to Amazon.com-style recommendations?  The examples here suggest possible pathways to an intelligent healthcare system with big data at its core.

“We have recommendations for you,” announces the website Amazon.com each time a customer signs in.   This mega-retailer analyzes billions of customers’ purchases—nearly $...
Jan, 01, 2012
Sensational Sequences

A new media artwork explores novel ways to represent and intuitively understand nature in the metagenomic era

What’s it like to be immersed in a dataset of millions of DNA sequences? Audiences of ATLAS in silico—a new media artwork that explores novel ways to represent and intuitively understand...
Sep, 30, 2008
Computing Has Changed Biology Forever

And people are starting to notice

In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Mar, 31, 2006
The Epigenome: A New View Into the Book of Life

There is growing recognition that epigenetics may be just as important as genetics in human health and disease.

In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
May, 31, 2010
Biology: A Game for a Crowd

Crowdsourced games and competitions fill an important niche

The rules of Phylo are simple: drag colored blocks across rows on the computer screen until similar colors line up. Within minutes of launching the game, any average person can learn how to play and...
Mar, 01, 2014
111 Reference Human Epigenomes Now Mapped

Different cell types intriguingly varied

Each cell in a person’s body contains the same three billion letter DNA encyclopedia. But the many different cell types throughout the body (brain, bone, heart, skin, etc.) represent different...
epigenetics
Jun, 01, 2015
The Uncertain Future of a Magazine

Why Biomedical Computation Review matters

Ten years ago, when Scott Delp, PhD, and Russ Altman, MD, PhD, decided to write a grant for a National Center for Biomedical Computing (NCBC), their brainstorming sessions with then-postdoc David...
Mar, 01, 2014
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