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The Microbiome: Dealing with the Data Deluge

Bioinformatics and computational biology enable microbiome research

This past June, 200 members of the NIH-funded Human Microbiome Project (HMP) Consortium published a slew of papers offering fresh insights into the role microbial communities play in the human body...
JGI, microbiome
Oct, 22, 2012
The Epigenome: A New View Into the Book of Life

There is growing recognition that epigenetics may be just as important as genetics in human health and disease.

In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
May, 31, 2010
Computing Has Changed Biology Forever

And people are starting to notice

In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Mar, 31, 2006
Betting on Genome Interpretation

Six startups jockey for a place at the table. Who will succeed?

A handful of startups are wagering that genome interpretation is the next big thing.    Why is this business space so hot?  “Once you can produce a better faster genome, thanks...
Jun, 20, 2013
The Landscape of Bioinformatics Education

Ever-Expanding and Heterogeneous

How universities are struggling to define core competencies, adapt to big data, and tailor curricula in this constantly changing interdisciplinary field   During the last ten years, the number...
Oct, 07, 2015
Mining Biomedical Literature: Using Computers to Extract Knowledge Nuggets

Researchers are not simply retrieving and repackaging what is already known, but are also deriving new knowledge by discovering connections that were previously unnoticed.

Not long ago, reading biomedical literature involved hours in the library combing through rows of dusty periodicals—not to mention pocketfuls of change for the copy machine. Now, although the...
Jun, 30, 2008
The Golden Age of Public Databases: Speeding Biomedical Discovery

Public databases impact not only how research is done but what kind of research is done in the first place.

The setting: a scientific conference in January 2008. The speaker, Bruce Ponder, MD, PhD, an oncology professor at Cambridge University, is describing a previously unknown link between a particular...
Sep, 30, 2008
111 Reference Human Epigenomes Now Mapped

Different cell types intriguingly varied

Each cell in a person’s body contains the same three billion letter DNA encyclopedia. But the many different cell types throughout the body (brain, bone, heart, skin, etc.) represent different...
epigenetics
Jun, 01, 2015
Untangling Integrative Analysis

How researchers are combining disparate data types and simulating systems that contain many different moving parts

13 years ago Markus Covert, PhD, read a New York Times article that changed his life.  The article quoted a prominent microbiologist who suggested that the ultimate test of one’s...
Feb, 15, 2013
Window into Microbial Behavior

Metagenomes give a picture of the genes driving metabolic processes important to bacterial growth and survival in different environments.

We know they are there, but most microbial denizens of deep oceans, sea floor vents, even our own intestines, remain a mystery. Because most microbes won’t grow in the lab, researchers have few...
Jun, 30, 2008
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