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The Epigenome: A New View Into the Book of Life

There is growing recognition that epigenetics may be just as important as genetics in human health and disease.

In the early 19th century, Jean-Baptiste Lamarck explained evolution as the inheritance of acquired traits; he believed that changes due to behaviors and exposures in one generation could be passed...
May, 31, 2010
111 Reference Human Epigenomes Now Mapped

Different cell types intriguingly varied

Each cell in a person’s body contains the same three billion letter DNA encyclopedia. But the many different cell types throughout the body (brain, bone, heart, skin, etc.) represent different...
epigenetics
Jun, 01, 2015
Computing the History of Life: Using New Data and New Models to Tackle Old Puzzles

Where did we come from? Ask a computer.

In 1977, the late Carl Woese, PhD, shook up biology when he published the first tree of life based on genetic sequence data. His team showed that, contrary to popular belief, eukaryotes did not...
Sep, 01, 2013
More Than Fate: Computation Addresses Hot Topics in Stem Cell Research

Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.

To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
stem cell
Mar, 31, 2010
Follow the Money: Big Grants in Biomedical Computing

A virtual lab rat; simulated DNA; an artificial pancreas; & integrating mental health data

Several biomedical computing projects received multi-million dollar funding in the fall of 2011, including efforts to: simulate the cardiac physiology of the rat; build a state-of-the-art DNA...
diabetes, DNA, Orozco, pancreas
Jan, 01, 2012
Network Biology—At the Frontier
Living systems are characterized by intricate networks of interactions among tens of thousands of entities within cells and across extracellular milieus. The entities in these networks include such...
Nov, 16, 2017
Big Data Feeds Understanding of Obesity

How data about genes, physical activity, and the environment are yielding insights about obesity

Despite extensive efforts, a clear understanding of the obesity epidemic remains elusive. Scientists have implicated specific causal genes (40 to 60 percent of obesity is considered heritable);...
Nov, 16, 2017
Career Paths

A Seller’s Market for Biomedical Data Science Jobs

Just pondering the current job market for biomedical data scientists is likely to put a smile on the faces of many in the field. “The bottom line is, compared to other disciplines,...
Oct, 07, 2015

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