i2b2 enables the use of existing clinical data for discovery research
In 2011, the FDA issued a black box warning on Celexa, one of the most widely prescribed antidepressants in the US. At higher doses, the drug had been linked to potentially dangerous changes in the...
Mar, 01, 2014
Computers and human experts duke it out over who is better at diagnosing disease, interpreting images, or predicting protein structure
Dorothy Rosenthal tenses over her microscope, peering at the problematic nucleus on the Pap smear yet again. “It’s abnormal,” she decides, and then hesitates. “No, it’s...
Jun, 30, 2006
From cellular responses to drugs, to adverse effects and drug repositioning, systems pharmacology gets the BD2K treatment
Relevant NIH Institutes:NCI, NHLBI, NIDDK, NINDS and all other disease-focused Institutes
The Big Data era in biomedicine offers a grand promise: that by crunching vast quantities of multi-...
Jun, 13, 2017
Computation strives to make prostate cancer less menacing
The numbers tell the story: Prostate cancer is a killer. It’s the second most common form of cancer and the second leading cause of cancer death among American men. More than 230,000 new cases...
Jun, 18, 2014
As algorithms evolve, computing power explodes, and scientists solve a greater number of 3-D protein structures, computer-aided design has the potential to dramatically cut the cost and time of drug discovery
Once upon a time, not long ago, HIV/AIDS was a scourge, killing anyone who contracted the deadly virus. Now, many people are living with the disease, which they control with drugs initially developed...
Jun, 30, 2007
Ontologies provide biomedical researchers with an inventory of the universal features of reality across organisms, biomedical disciplines, and levels of granularity. In capturing what is universal,...
Jun, 30, 2009
Cardiovascular models are moving to the bedside
Pacemakers, heart-lung machines, stents and artificial hearts all sprang from successful partnerships between engineers and doctors. “From its inception in the 1950s, heart surgery has...
Mar, 01, 2014
Exceptional computational detective work has the potential to reshape our understanding of when and why diseases strike
Relevant NIH Institutes: NCI, NHLBI, NIAMS, NIA, NINDS, NCATS, and all other disease-focused Institutes
Most people don’t know that they’re sick until they feel, for lack of a...
Jun, 14, 2017
There are numerous musculoskeletal modeling methods available to make predictions of muscle and joint contact forces. While such predictions can help improve treatments for movement-related disorders...
Jan, 01, 2012
Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.
To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
Mar, 31, 2010
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