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i2b2 Goes Viral: Open-Source Platform Enables Clinical Research

i2b2 enables the use of existing clinical data for discovery research

In 2011, the FDA issued a black box warning on Celexa, one of the most widely prescribed antidepressants in the US. At higher doses, the drug had been linked to potentially dangerous changes in the...
Mar, 01, 2014
Human Versus Machine: Biomedical expertise meets computer automation

Computers and human experts duke it out over who is better at diagnosing disease, interpreting images, or predicting protein structure

Dorothy Rosenthal tenses over her microscope, peering at the problematic nucleus on the Pap smear yet again. “It’s abnormal,” she decides, and then hesitates. “No, it’s...
Jun, 30, 2006
Big Data and Drugs: BD2K Centers Solidify Emerging Approaches

From cellular responses to drugs, to adverse effects and drug repositioning, systems pharmacology gets the BD2K treatment

Relevant NIH Institutes:NCI, NHLBI, NIDDK, NINDS and all other disease-focused Institutes   The Big Data era in biomedicine offers a grand promise: that by crunching vast quantities of multi-...
Jun, 13, 2017
Prostate Cancer: Crunching the Numbers

Computation strives to make prostate cancer less menacing

The numbers tell the story: Prostate cancer is a killer. It’s the second most common form of cancer and the second leading cause of cancer death among American men. More than 230,000 new cases...
Jun, 17, 2014
Dock This: In Silico Drug Design Feeds Drug Development

As algorithms evolve, computing power explodes, and scientists solve a greater number of 3-D protein structures, computer-aided design has the potential to dramatically cut the cost and time of drug discovery

Once upon a time, not long ago, HIV/AIDS was a scourge, killing anyone who contracted the deadly virus. Now, many people are living with the disease, which they control with drugs initially developed...
Jun, 30, 2007
Canonicity and Disease Ontologies
Ontologies provide biomedical researchers with an inventory of the universal features of reality across organisms, biomedical disciplines, and levels of granularity. In capturing what is universal,...
Jun, 30, 2009
Doing the Heart Good: Translating Models to the Clinic

Cardiovascular models are moving to the bedside

Pacemakers, heart-lung machines, stents and artificial hearts all sprang from successful partnerships between engineers and doctors. “From its inception in the 1950s, heart surgery has...
cardiovascular, clinical, translation
Mar, 01, 2014
Disease Detectives: BD2K Center Researchers Sleuth for Early Signs of Disease

Exceptional computational detective work has the potential to reshape our understanding of when and why diseases strike

Relevant NIH Institutes: NCI, NHLBI, NIAMS, NIA, NINDS, NCATS, and all other disease-focused Institutes   Most people don’t know that they’re sick until they feel, for lack of a...
Jun, 14, 2017
Grand Challenge Competition Provides Rich Data Set to Improve Joint Contact Force Predictions
There are numerous musculoskeletal modeling methods available to make predictions of muscle and joint contact forces. While such predictions can help improve treatments for movement-related disorders...
knee
Jan, 01, 2012
More Than Fate: Computation Addresses Hot Topics in Stem Cell Research

Using computational models, researchers are gaining traction toward understanding what makes a stem cell a stem cell; how gene expression drives stem cell differentiation; why studying stem cell heterogeneity is important; and, ultimately, how stem cells control their fate.

To the casual observer, stem cells offer the almost magical promise of—Voila!—turning into exactly the kind of cell needed to repair an injured spinal cord or replace a damaged organ. And...
stem cell
Mar, 31, 2010
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