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Computing Has Changed Biology Forever

And people are starting to notice

In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Mar, 31, 2006
Computing Better Enzymes: Optimizing Directed Evolution

Using computation, researchers narrow the search space for directed evolution; guide mutagenesis; and create de novo enzymes

Enzymes are among nature’s crowning achievements: they accelerate chemical reactions, making life possible. People have co-opted natural enzymes for industrial use for thousands of years (think...
Feb, 19, 2013
It Takes a Village: Building the Next Generation of Biomedical Ontologies
Although the notion of ontology has been around since Aristotle, the perceived need to develop ontologies in biomedicine has accelerated in recent years as investigators attempt to make sense of the...
Dec, 31, 2008
Computing Gene Interactions: Functional and Statistical Approaches Converge

Epistasis explored

When people work together, some individuals may hinder team performance—essentially masking the abilities of other members—while others may boost the group’s performance beyond the...
epistasis
Aug, 31, 2011
What Value Could Fractals Add to Biomedical Image Analysis?

Could fractals join the collection of mathematical gems that propel biomedical image analysis to new heights?  

We collect large amounts of biomedical image data, hoping to glean insights into our biological world. While deep learning has become popular for finding features that, for example, distinguish...
Nov, 16, 2017
Computing the Ravages of Time: Using Algorithms To Tackle Alzheimer’s Disease

Biomarker research, genetics, and imaging are all coming into play

In 1906, at a small medical meeting in Tübingen, Germany, physician Alois Alzheimer gave a now-famous presentation about a puzzling patient. At age 51, Auguste D.’s memory was failing...
Sep, 30, 2007
The NCBC Centers: Incubators for the Next Generation of Science and Scientists

The NCBCs legacy of human capital

In this issue of Biomedical Computation Review, we feature a look at the NIH Roadmap National Centers for Biomedical Computing (NCBC) program. The NCBC program was a response to the recommendations...
Oct, 19, 2012
Successful Collaborations: Helping biomedicine and computation play well together

Collaborations are a fact of life for interdisciplinary fields like biomedical computing, and social scientists can help researchers understand how to make them more productive

Social scientists who study science have noticed a trend: More and more researchers are collaborating. Over the last twenty years, the number of co-authored papers has increased in every scientific...
Jun, 30, 2008
Brain Chips

A new technique for measuring neuronal activity on a chip

Neurons are tough cells to study. There are a staggering number of them in most animals, and they are constantly talking with one another. One way to look at groups of neurons in real-time is to take...
Sep, 30, 2010
Bringing Supercomputers to Life (Sciences)

Supercomputers open up new horizons, offering the possibility of discovering new ways to understand life’s complexity

Their very names sound like dinosaurs. Teracomputers. Petacomputers. These are, in fact, the dinosaurs of the digital world—monstrous, hungry and powerful. But unlike the extinct...
Sep, 30, 2006
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