And people are starting to notice
In 1991, a prescient editorial in Nature by Harvard’s Walter Gilbert, PhD, (“Towards a paradigm shift in biology”) included these observations on the utility and impact of computing...
Apr, 01, 2006
Using computation, researchers narrow the search space for directed evolution; guide mutagenesis; and create de novo enzymes
Enzymes are among nature’s crowning achievements: they accelerate chemical reactions, making life possible. People have co-opted natural enzymes for industrial use for thousands of years (think...
Feb, 19, 2013
Although the notion of ontology has been around since Aristotle, the perceived need to develop ontologies in biomedicine has accelerated in recent years as investigators attempt to make sense of the...
Jan, 01, 2009
Epistasis explored
When people work together, some individuals may hinder team performance—essentially masking the abilities of other members—while others may boost the group’s performance beyond the...
Sep, 01, 2011
Biomarker research, genetics, and imaging are all coming into play
In 1906, at a small medical meeting in Tübingen, Germany, physician Alois Alzheimer gave a now-famous presentation about a puzzling patient. At age 51, Auguste D.’s memory was failing...
Oct, 01, 2007
The NCBCs legacy of human capital
In this issue of Biomedical Computation Review, we feature a look at the NIH Roadmap National Centers for Biomedical Computing (NCBC) program. The NCBC program was a response to the recommendations...
Oct, 19, 2012
Collaborations are a fact of life for interdisciplinary fields like biomedical computing, and social scientists can help researchers understand how to make them more productive
Social scientists who study science have noticed a trend: More and more researchers are collaborating. Over the last twenty years, the number of co-authored papers has increased in every scientific...
Jul, 01, 2008
A new technique for measuring neuronal activity on a chip
Neurons are tough cells to study. There are a staggering number of them in most animals, and they are constantly talking with one another. One way to look at groups of neurons in real-time is to take...
Oct, 01, 2010
Supercomputers open up new horizons, offering the possibility of discovering new ways to understand life’s complexity
Their very names sound like dinosaurs. Teracomputers. Petacomputers. These are, in fact, the dinosaurs of the digital world—monstrous, hungry and powerful. But unlike the extinct...
Oct, 01, 2006
Anton: A computer dedicated to molecular dynamics simulations.
In biology, many exciting events happen on the millisecond timescale—proteins fold, channels open and close, and enzymes act on their substrates. Atomic-level simulations of this duration are...
Oct, 01, 2008
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