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Computational Approaches to Design Vaccines Faster

Systematic vaccine design offers hope of vaccines to prevent HIV or treat cancer

Like a “Wanted” poster distributed to a posse, peptide vaccines show the immune system a small sample (about eight amino acids) of a pathogen, training the body to seek and destroy...
Aug, 31, 2013
Packing It All In: Curricula for Biomedical Computing

Balancing Breadth and Depth

The last decade saw a proliferation of training programs at the intersection of life science and computation, with more than 60 new degree and certificate programs launched in the United States alone...
Aug, 31, 2005
Fulfilling the Promise of the NIH Roadmap Through National Engagement by the National Centers for Biomedical Computing (NCBC) and the CTSA Informatics
For major team-based Roadmap initiatives, National Institutes of Health (NIH) officials expect grantees to look beyond the focus of their individual projects to build bridges not only among funded...
Sep, 30, 2008
Tool Dissemination—Doing It Right
Biomedical computing at academic research centers has been compared to a cottage industry. Lots of individuals work away on their focused research projects, generating useful algorithms. But quite...
Dec, 31, 2008
Early BLAST Off

Bringing Bioinformatics to Secondary Schools

Two decades ago at a genomics workshop for educators, a high school biology teacher isolated DNA from a snippet of his hair and got it sequenced. He then used a computer algorithm to compare his DNA...
Oct, 05, 2015
Simulation Simplified

Simbody introduces the concept of a “mobilizer,” which directly expresses a part’s movement, however complex, purely in relation to another part

Typically, researchers who simulate life in motion—from particles to people—start by describing the motion of each part of an object independently of the other parts. Additional equations...
Dec, 31, 2007
An insider’s view of biological structures
In March, Simbios released version 1.0 of the SimTK Simulation toolkit. A cornerstone of this release is Simbody, a new piece of the open-source SimTK Core toolkit for physics-based simulation....
Mar, 31, 2008
The Landscape of Bioinformatics Education

Ever-Expanding and Heterogeneous

How universities are struggling to define core competencies, adapt to big data, and tailor curricula in this constantly changing interdisciplinary field   During the last ten years, the number...
Oct, 07, 2015
Single-Cell Genomics: Can Bioinformatics Unlock its Potential?

The tools to sequence the genomes of individual cells yield data that’s noisy and somewhat unreliable. What bag of tricks can bioinformaticians use to address these challenges?

To study genomes, researchers have typically pooled the genetic material from thousands of cells together. But this approach can only get at “average genomes” or “average...
Mar, 31, 2016
BENCH-SIDE COMPUTATION: New Tools to Accelerate Experimental Research

It’s impossible to predict what the hottest new tools will be, but here are a few gems that caught our attention

Many experimental researchers rely on computational tools to push the pace and productivity of laboratory research. It’s impossible to predict what the hottest new tools will be, but this...
protein dynamics, simulation, visual system
Mar, 31, 2011
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